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Image Search Results
Journal: BMJ Case Reports
Article Title: ARHGEF9 disruption in a female patient is associated with X linked mental retardation and sensory hyperarousal
doi: 10.1136/bcr.06.2009.1999
Figure Lengend Snippet: Bacterial artificial chromosome (BAC) position on the X chromosome with fluorescent in situ hybridisation (FISH) results
Article Snippet: The
Techniques: In Situ, Hybridization
Journal: BMJ Case Reports
Article Title: ARHGEF9 disruption in a female patient is associated with X linked mental retardation and sensory hyperarousal
doi: 10.1136/bcr.06.2009.1999
Figure Lengend Snippet: Fluorescent in situ hybridisation (FISH) mapping of the centromeric and telomeric breakpoints with bacterial artificial chromosomes (BACs). (A) FISH with BAC RP11-570J18 shows equal hybridisation at two loci on the inverted X chromosome (arrow) relative to one locus on the unaffected X (arrow head). (B) FISH with RP11-73M8 reveals unequal hybridisation at two loci confirming and narrowing the breakpoint interval (arrow); unaffected X (arrow head). (C) Bracketed region on genome schematic (Xq11.1) outlines estimated breakpoint region as defined by these FISH results (BACs listed in table 1). The centromeric breakpoint lies between ARHGEF9 exons 1–3. (D) Bracketed region on genome schematic (Xq27.2-27.3) depicts estimated telomeric breakpoint region. (FISH data not shown).
Article Snippet: The
Techniques: In Situ, Hybridization